Den kommer i marts 2018 og bliver instrueret af David Leitch (John Wick). Indtil videre er Ryan Reynolds eneste navn på rollelisten.
As teased in the post credits sequence on the first film, Deadpool 2 will introduce Cable, the time traveling son of the X-Men’s Cyclops. The character has one of the comic book medium’s more complicated origin stories, so it remains to be seen what will go into the backstory of the big screen Cable. The role is currently being cast and, while rumors have been quite prevalent, an actor has not yet been selected for the role. Meanwhile, Deadpool 2 is also said to feature the luck-altering mutant Domino. Her casting has, likewise, not yet been confirmed by the studio.